Drug Standards
Selleck Chemical LLC Tofacitinib (CP-690550) 5mg 477600-75-2 Tasocitinib
Tofacitinib (CP-690550,Tasocitinib) is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. Tofacitinib inhibits the expression of antiapoptotic BCL-A1 and BCL-XL in human plasmacytoid dendritic cells (PDC) and induced PDC apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC Lapatinib Ditosylate 388082-77-7 50mg
Lapatinib Ditosylate (CAS 388082-77-7) is a reversible dual inhibitor of the ErbB-2 (HER2) and epidermal growth factor receptor (EGFR) tyrosine kinases It competitively binds to the ATP-binding sites of these receptors preventing activation and downstream signaling In vitro Lapatinib Ditosylate exhibits potent inhibition with IC50 values of 9 2 nM for ErbB-2 and 10 8 nM for EGFR and demonstrates over 300-fold selectivity compared to kinases such as MEK and ERK The compound suppresses proliferation and downstream phosphorylation events (Erk1/2 AKT) in cancer cell lines overexpressing ErbB-2/EGFR and induces G1 cell cycle arrest In vivo it reduces tumor growth in xenograft mouse models Lapatinib Ditosylate is widely utilized in studies exploring receptor tyrosine kinase function and targeted cancer therapies
Apexbio Technology LLC Esomeprazole Magnesium trihydrate 217087-09-7 200mg
Esomeprazole Magnesium trihydrate (CAS 217087-09-7) is the S-enantiomer of omeprazole formulated as a magnesium salt It functions as a proton pump inhibitor selectively inhibiting the H /K -ATPase enzyme in gastric parietal cells to suppress gastric acid secretion This compound demonstrates pH-dependent stability degrading rapidly in acidic environments while remaining stable under alkaline conditions Controlled clinical studies have demonstrated that esomeprazole reduces the incidence of gastroduodenal ulcers by 70 85% and lowers gastrointestinal bleeding risk by up to 90% in at-risk populations It serves as a valuable tool for research into acid-related gastrointestinal disorders
Apexbio Technology LLC Betamethasone Dipropionate 5593-20-4 10mM (in 1mL DMSO)
Betamethasone Dipropionate (CAS 5593-20-4) is a synthetic glucocorticoid receptor agonist targeting intracellular glucocorticoid receptors It is designed to activate these receptors thereby modulating inflammatory and immune response pathways Betamethasone Dipropionate exerts its biological activity primarily through enhancement of glucocorticoid receptor-mediated gene transcription leading to suppression of inflammatory mediator production and inhibition of inflammatory cell recruitment Based on these pharmacological properties Betamethasone Dipropionate holds research potential in investigations of glucocorticoid signaling inflammatory skin disorders (such as dermatosis) and topical drug formulation research aimed at optimizing local delivery while minimizing systemic effects
Medchemexpress LLC Latanoprost acid | 41639-83-2 | 95.1% | 390.51 | 50 MG
Latanoprost acid, an analog of prostaglandin (PG) F2α, is a selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor. It inhibits RANKL-induced osteoclastogenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, followed by the c-fos/NFATc1 pathway. Latanoprost acid is a medication used to lower pressure inside the eyes.
- Selective prostanoid receptor (FP) agonist
- Specifically activates the FP-PG receptor
- Inhibits RANKL-induced osteoclastogenesis and function
- Inhibits ERK, AKT, JNK, and p38 cascade
- Inhibits the c-fos/NFATc1 pathway
- Lowers pressure inside the eyes
- Reduces the protein expressions of c-fos and NFATc1 in vitro
- Significantly inhibits mature osteoclast formation in vitro
- Notably prevents LPS-induced bone destruction in vivo
Medchemexpress LLC (rel)-Tivantinib | 905853-99-8 | 96.5% | C23H19N3O2 | 1 ML
(rel)-Tivantinib is a potent and highly selective inhibitor of the receptor tyrosine kinase c-MET. It also targets GSK3α and GSK3β, which are significant in the cellular mechanism of non-small cell lung cancer (NSCLC). This product is intended for research use only.
- Potent and highly selective inhibitor of c-MET
- Targets GSK3α and GSK3β
- Important in the cellular mechanism of non-small cell lung cancer (NSCLC)
- For research use only
Cayman Chemical OxIbendazole 50mg
A benzimidazole anthelmintic; inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin and inhibits mammalian tubulin polymerization (IC50s = 0.3 and 2.2 µM, respectively); reduces fecal worm egg counts in dogs and cats by greater than 90% for the nematodes T. canis, T. vulpis, A. caninum, and T. leonine at 15 mg/kg in combination with niclosamide; reduces fecal egg counts of strongyles in horses at 10 mg/kg per day
Sigma Aldrich Fine Chemicals Biosciences Aspirin United States Pharmacopeia (USP) Reference Standard | 50-78-2 | MFCD00002430 | 500MG
Aspirin United States Pharmacopeia (USP) Reference Standard | Mol Wt: 180.16 | 50-78-2 | MFCD00002430 | 500MG
Sigma Aldrich Fine Chemicals Biosciences Guaiacol United States Pharmacopeia (USP) Reference Standard | 90-05-1 | MFCD00002185 | 1G
Guaiacol United States Pharmacopeia (USP) Reference Standard | Mol Wt: 124.14 | 90-05-1 | MFCD00002185 | 1G
Medchemexpress LLC Oxytetracycline | 79-57-2 | 99.2% | 460.43 | 100 MG
Oxytetracycline is an antibiotic belonging to the tetracycline class. It potently inhibits Gram-negative and Gram-positive bacteria. This compound acts as a protein synthesis inhibitor, preventing the binding of aminoacyl-tRNA to the ribosomal RNA complex. It also exhibits anti-HSV-1 activity. This product is for research use only.
- Potently inhibits gram-negative and gram-positive bacteria
- Functions as a protein synthesis inhibitor
- Prevents aminoacyl-tRNA binding to the ribosomal RNA complex
- Exhibits anti-HSV-1 activity
- Microbial metabolite and aromatic polyketide
- Available as a solid
Medchemexpress LLC Osimertinib dimesylate | 2070014-82-1 | 99.19% | C30H41N7O8S | 1 ML
Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor with IC50s of 12 and 1 nM against EGFRL858R and EGFRL858R/T790M, respectively. This product is intended for research use only.
- Purity: 99.19%
- CAS number: 2070014-82-1
- Solubility: 10 mM * 1 mL in water (ready for reconstitution)
- Data sheet, certificate of analysis, safety data sheet, and handling instructions are available
- For research use only
Selleck Chemical LLC Raltegravir (MK-0518) 10mM/1mL 518048-05-0
Raltegravir (MK-0518) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM in cell-free assays, respectively. It shows greater than 1000-fold selectivity for HIV-1 IN over several related Mg2+-dependent enzyme such as HCV polymerase, HIV reverse transcriptase, HIV RNaseH and human ?-, ?-, ?-polymerases. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Sigma Aldrich Fine Chemicals Biosciences 1-Butanol United States Pharmacopeia (USP) Reference Standard | 71-36-3 | MFCD00002964 | 3X1.2ML
1-Butanol United States Pharmacopeia (USP) Reference Standard | Mol Wt: 74.12 | 71-36-3 | MFCD00002964 | 3X1.2ML
Apexbio Technology LLC Ketorolac 74103-06-3 200mg
Ketorolac (CAS 74103-06-3) is a non-steroidal anti-inflammatory compound characterized by its non-selective inhibition of cyclooxygenase (COX) isoenzymes By suppressing COX-mediated conversion of arachidonic acid to prostaglandins ketorolac modulates inflammatory processes pain signaling and fever responses at the molecular level It is widely employed in biomedical research to investigate prostaglandin-dependent pathways and to model the pharmacological consequences of COX inhibition in cellular and in vivo systems